Poznato je da istovremeno uzimanje diazepama i kombinovanih oralnih kontraceptiva može dovesti do probojnog krvarenja. Mehanizam ove reakcije nije poznat. Nisu prijavljeni slučajevi neuspele kontracepcije.
Obustavljanje može takođe izazvati neuobičajeno ponašanje, uključujući agresivne ispade, uzbuđenje ili depresiju sa samoubilačkim mislima ili ponašanjem.
Upotreba diazepama kod pacijenata sa oštećenjem funkcije jetre može dovesti do kome, pa je zato potrebno smanjiti dozu ili razmotriti primenu drugog leka. Kod pacijenata sa teškim oštećenjem funkcije bubrega takođe treba smanjiti dozu.
U slučajevima gubitka ili ožalošćenosti, psihološko prilagođavanje može biti inhibirano primenom benzodiazepina.
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